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In a 2-year carcinogenicity study in Sprague Dawley rats, subcutaneous doses of 0.0025, 0.01, 0.025 and 0.1 mg/kg/day were administered (below quantification, 0.4-, 1-, and 6-fold the exposure at the MRHD)
Real-time qPCR The mRNA transcript levels of TF, ferroportin1 (FPN1), FTL, FTH1, NCOA4, HERC2, ATG 5, and ATG7 in human granulosa cells were analyzed by RT-PCR
The National Institute for Health and Care Excellence (NICE) provides guidance on the use of GLP-1 receptor agonists in guideline NG28, recommending them for type 2 diabetes in specific contexts, such as when other therapies have proven inadequate, particularly in people with higher BMI or cardiovascular risk factors
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